13
Sep
Testing done following each cisplatin cycle showed increasingly progressive hearing loss in the mice. Researching online, it looks like cisplatin definitely has hearing loss as a common side effect, along with ringing in the ears (tinnitus).
Of the 101 participants, hearing loss occurred in 29 (63%) of the children who received cisplatin alone, compared with 18 (33%) of those who also got sodium thiosulfate.
Cisplatin and hearing loss. Cisplatin is a medicine given to cancer patients during chemotherapy. Vestibulotoxicity of aminoglycosides can manifest as loss of balance with or without vertigo. Vestibulotoxicity of aminoglycosides can manifest as loss of balance with or without vertigo.
Although the experiments were conducted on rats, the results showed that caffeine and cisplatin do indeed affect hearing. Increasing cisplatin dose appeared significantly related to hearing loss among germ cell tumor survivors, according to study results. Pretreatment and posttreatment audiograms were collected within 90 days of initiation and completion of cisplatin therapy.
Researching online, it looks like cisplatin definitely has hearing loss as a common side effect, along with ringing in the ears (tinnitus). Hearing loss induced by cisplatin or aminoglycosides is generally bilateral and begins at high frequencies, extending to lower frequencies with prolonged treatment. As with leukopenia, hearing loss and dizziness often occurred after several weeks of administration.
Language and communication are fundamental for psychosocial development, cognition, learning, and. Hearing loss can result from cisplatin therapy for cancer. The drugs cause permanent hearing loss in 40 to 80 percent of adult patients and at least half of the children who receive the drug.
The researchers also measured platinum levels in various organs throughout the drug cycles and found that, whereas other organs eliminated the drug relatively quickly, the cochlea retained the cisplatin, showing no significant loss of platinum 60 days. For frequencies above 8 khz the average hearing loss stood at. Coradini et al., 2007 ).
Patients treated with cisplatin were observed in an otoneurological study with special reference to cochlear and vestibular toxicity. Cisplatin was the only chemotherapy drug received by participants in the trial. The medicine has several side effects, including hearing loss and tinnitus.
Loss of hearing at this developmental stage hampers the. Three years after treatment, 98% of the children who received cisplatin and sodium thiosulfate. Testing done following each cisplatin cycle showed increasingly progressive hearing loss in the mice.
The findings of this research suggest that audiological assessments in between cycles of cisplatin may be necessary for children under the age of 5. Of the 101 participants, hearing loss occurred in 29 (63%) of the children who received cisplatin alone, compared with 18 (33%) of those who also got sodium thiosulfate. Cisplatin induced hearing loss is usually bilateral and irreversible, and is particularly serious in the pediatric population (age 6 months and onwards) with cancers like neuroblastomas, cns malignancies, head and neck cancers, where irradiation of the base of the skull or brain is also performed (chen et al.
The study establishes the first. In some cases, chemotherapy drugs can be ototoxic, which means they are harmful to hearing. Cisplatin therapy is used in a variety of treatment protocols, but it is most commonly used in gynecological (ovarian and cervical) and head and neck cancers.
Permanent hearing loss is a common side effect of this medication, but until now, studies have been too small and too varied to accurately characterize this risk. For patients treated with the chemotherapeutic drug cisplatin, one common consequence of treatment is permanent hearing loss. It is bilateral and permanent and severely affects the quality of life for cancer patients.
Reported rates of cisplatin ototoxicity vary widely, though it is believed that at least half of all patients treated with cisplatin will suffer hearing loss.